"It has been 25 years since the first edition of Molecular Biology of the Cell (MBoC) was published, which means that roughly half of today's practicing scientists do not remember life without this cell biology `bible'. The other half might recall how the book almost instantly filled a void with refreshingly clear and engaging writing illustrated with extensive diagrams and figures....MBoC has only improved over its several editions, growing with the rapid advances in the field to become an essential resource for students at all levels and a trusted first stop for researchers transitioning into unfamiliar areas of cell biology....An enduring strength of the book is that it remains a comprehensive textbook....In addition to the comprehensive updating of every chapter, another reason to consider acquiring edition five is the improved integration of the print volume with an extensive array of videos and animations in the `Cell Biology Interactive' provided on the accompanying DVD....Another welcome improvement in MBoC5 helps link the textbook to the lab - there are now problems printed at the ends of the first 20 chapters. Whereas some are designed to facilitate information retention, the best problems stimulate thought and challenge the reader to think about experimental approaches for learning new things about cell biology....the MBoC5 package is a fantastic resource and well worth the upgrade." --Development (Company of Biologists) 135, 3973-3974 (2008)